Optimization and applications of an in vivo bioluminescence imaging model of influenza a virus infections

Highlights
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The in vivo BLI model of IAV infections can simplify the determination of viral load in living animals.

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The in vivo BLI model of IAV infections allow longitudinal measurements of virus infection/spread in living animals.

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The in vivo BLI model of IAV infections improved the throughput of animal models.

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The advanced BLI models can facilitate studies in both basic and applied virology.