WHO launches new global influenza strategy    
submitted by kickingbird at Mar, 12, 2019 from WHO
WHO released a Global Influenza Strategy for 2019-2030 aimed at protecting people in all countries from the threat of influenza. The goal of the strategy is to prevent seasonal influenza, control the spread ...

USCDC: A(H5N1) Bird Flu Response Update October 11, 2024    
submitted by kickingbird at 4 hours ago from USCDC
October 11, 2024 – CDC continues to respond to the public health challenge posed by a multistate outbreak of avian influenza A(H5N1) virus, or "H5N1 bird flu," in dairy cows, poultry and other animals ...

GISAID: H5N1 Bird Flu Circulating in Dairy Cows in the United States    
submitted by kickingbird at 1 days ago from GISAID
The 2.3.4.4b clade of the highly pathogenic avian influenza (HPAI) virus causing outbreaks in wild and domestic birds around the world, continues to spread in dairy farms across the United States since ...

US: CDC Confirms 3rd Human Case of H5 Bird Flu in California    
submitted by kickingbird at 2 days ago from USCDC
The Centers for Disease Control and Prevention (CDC) has confirmed a third human case of H5 bird flu in California. Like the two cases in that state confirmed last week, the person reported occupational ...

GISAID: H5N1 Bird Flu Circulating in Dairy Cows in the United States    
submitted by kickingbird at 4 days ago from GISAID
The 2.3.4.4b clade of the highly pathogenic avian influenza (HPAI) virus causing outbreaks in wild and domestic birds around the world, continues to spread in dairy farms across the United States since ...

Joseph D. Trimarco, etc.,al. Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions. Virology，10 Oct 2024.  Abstract  
submitted by kickingbird at 15 minute(s) ago from Virology，10 Oct 2024
In early 2024, a clade 2.3.4.4b high pathogenic H5N1 avian influenza virus was detected in dairy cows and humans in the United States. Since then, it has spread to herds in at least 13 states and caused ...

María Ríos Carrasco, Andrea Gr?ne, Judith M. A. v. The mammary glands of cows abundantly display receptors for circulating avian H5 viruses. Virology， 10 Oct 2024.  Abstract  
submitted by kickingbird at 13 hours ago from Virology， 10 Oct 2024
Influenza A viruses (IAVs) from the H5N1 2.3.4.4b clade are circulating in dairy farms in the USA.; ruminants were presumed not to be hosts for IAVs. Previously, IAV-positive mammalian species were hunters ...

Jarek Juraszek, etc.,al. Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH-switches. PNAS Nexus.  Abstract  
submitted by kickingbird at 13 hours ago from PNAS Nexus
Vaccine components based on viral fusion proteins require high stability of the native prefusion conformation for optimal potency and manufacturability. In the case of influenza B virus hemagglutinin (HA), ...

Owuor DC, Ngoi JM, Nyasimi FM, Murunga N, Nyiro JU. Local patterns of spread of influenza A H3N2 virus in coastal Kenya over a 1-year period revealed through virus sequence data. Sci Rep. 2024 Oct 8;14(1):23426.  Abstract  
submitted by kickingbird at 13 hours ago from Sci Rep. 2024 Oct 8;14(1):23426
The patterns of spread of influenza A viruses in local populations in tropical and sub-tropical regions are unclear due to sparsity of representative spatiotemporal sequence data. We sequenced and analyzed ...

Zhang K, Cagatay T, Xie D, Angelos AE, Cornelius S. Cellular NS1-BP Protein Interacts with the mRNA Export Receptor NXF1 to Mediate Nuclear Export of Influenza Virus M mRNAs. J Biol Chem. 2024 Oct 7:107871.  Abstract  
submitted by kickingbird at 13 hours ago from J Biol Chem. 2024 Oct 7:107871
Influenza A viruses have eight genomic RNAs that are transcribed in the host cell nucleus. Two of the viral mRNAs undergo alternative splicing. The M1 mRNA encodes the matrix protein 1 (M1) and is also ...